Epidemiological Research

The epidemiological research projects that are currently being implemented by the GPR ICARE team at LVPEI are:-

Assessing the incidence and progression of age-related eye diseases in a longitudinal cohort from Southern India (Andhra Pradesh Eye Disease study-III)

Supported by Lions Clubs International Foundation (LCIF)

This study is a follow-up to the first phase of a population based study "The Andhra Pradesh eye Disease Study (APEDS)" conducted in 1996-2000. The study provided prevailing data on eye diseases and burden of blindness and visual impairment in the state of Andhra Pradesh (India). Participants who were examined during the first phase in rural areas in the earlier study were again examined (only the available ones). Data collection for this study was completed in April 2016 with the below listed primary and secondary objectives:-

Primary Objectives

  1. To assess the cumulative incidence (i.e. new cases) of and risk factors for blindness, visual impairment (VI), cataract, diabetic retinopathy, refractive error and glaucoma in those 30 years and above.
  2. To assess the cumulative incidence (i.e. new cases) of and risk factors for refractive error (myopia) in those 10-29 years.
  3. To investigate progression of and risk factors for blindness/VI, refractive error, lens opacities; glaucoma; diabetic retinopathy
  4. To investigate progression of and risk factors for myopia among those with myopia aged 10-29 years

Secondary Objectives

  1. To describe the rate of diabetes, and age related macular degeneration (ARMD) in the surviving cohort
  2. To assess self reported visual function among those with blindness and VI (<6/18 in better eye and and >30 years of age) due to these age related causes in APEDS III.
  3. To understand the changing pattern of barriers of uptake of eye care services and knowledge of eye diseases in a subset of population (Those 30 years and above)
  4. To determine the risk of chronic diseases associated with specific gene variant(s) in the genome and estimate population attributable risks for them for devising a risk assessment chip.
  5. To identify genetic risk factors for quantitative traits such as Intraocular pressure (IOP), central corneal thickness (CCT), cup to disk ratio etc. in the APEDS cohort as candidates for disease susceptibility.
  6. To determine gene/environment and gene/gene interactions for chronic eye diseases in APEDS and compare them in conjunction with pooled dataset from other populations.



Prevalence, Causes and Risk Factors for Blindness and Low Vision in Children in Krishna District of Andhra Pradesh, India

Supported by Lions Clubs International Foundation (LCIF)

The aim of the study is to provide the estimates of the prevalence, causes and risk factors for childhood related diseases. The project is ongoing in Krishna District, Andhra Pradesh (AP), India where L V Prasad Eye Institute (LVPEI) has existing Vision Centres (VC) which are connected to its tertiary eye hospital in that district. 80,000 Children will be covered for screening and referral services under this project. The project started on June 2015 and data collection is ongoing. Lions Clubs International Foundation (LCIF) - Sight first grant is supporting LVPEI to implement this project.

Primary Objective

  1. To estimate prevalence, causes and risk factors for blindness (BL) and low vision (VL) in children

Secondary Objectives

  1. To assess Knowledge, Attitude and Practices (KAP) of parents for the uptake of eye care services in children
  2. To understand barriers in accessing eye care services including low vision and rehabilitation services


Completed Projects details - PDF document

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